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投稿信
Dear Editor,We would like to submit the enclosed manuscript entitled “GDNF Acutely
Modulates Neuronal Excitability and A-type Potaium Channels in Midbrain
Dopaminergic Neurons”, which we wish to be considered for publication in Nature
Neuroscience.The further information about the paper is in the following:
GDNF has long been thought to be a potent neurotrophic factor for the survival
of midbrain dopaminergic neurons, which are degenerated in Parkinson’s disease.In
this paper, we report an unexpected, acute effect of GDNF on A-type potaium
channels, leading to a potentiation of neuronal excitability, in the dopaminergic
neurons in culture as well as in adult brain slices.Further, we show that GDNF
regulates the K+ channels through a mechanism that involves activation of MAP
kinase.Thus, this study has revealed, for the first time, an acute modulation of ion
channels by GDNF.Our findings challenge the claic view of GDNF as a long-term
survival factor for midbrain dopaminergic neurons, and suggest that the normal
function of GDNF is to regulate neuronal excitability, and consequently dopamine
release.These results may also have implications in the treatment of Parkinson’s
disease.We also confirm that this paper has not been published elsewhere nor has
been submitted for publication elsewhere.Thank you for your consideration.Sincerely yours
Jason Liu
Addre:Department of Faculty of Light and Chemical,Guangdong University of Technology,Guangzhou, Guangdong, 510006,P.R.China
E-mail:XXXXX@mail.gdut.edu.cn
Tel:86-551-36XXXXX
Fax:86-551-36XXXXX
求职信
April 20, 2011
P.O.Box 3
GDUT University
Guangzhou, Guangdong, 510006
The People’s Republic of China
Dear Sir／Madame,Your advertisement for a Network Maintenance Engineer in the April 10 Student Daily interested me because the position that you described sounds exactly like the kind of job I am seeking.According to the advertisement, your position requires a good university degree Bachelor or above in Computer Science or equivalent field and proficient in Windows NT 4.0and Linux System.I feel that I am competent to meet the requirements.I will be graduating from GDUT University this year with a MSC.My studies have included courses in computer control and management and I designed a control simulation system developed with Microsoft Visual and SQL Server.During my education, I have grasped the principles of my major subject area and gained practical skills.Not only have I paed CET-6, but more importantly I can communicate fluently in English.My ability to write and speak English is a good standard.I would welcome an opportunity to attend you for an interview.Enclosed is my resume and if there is any additional information you require, please contact me.Sincerely yoursJason Liu
