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Abstract Autophagy is a central proce in regulation of cell survival, cell death and proliferation and plays an important role in carcinogenesis, including thyroid carcinoma.Genetic variation in autophagy components has been demonstrated to influence the capacity to execute autophagy and is aociated with disease susceptibility, progreion and outcome.In the present study, we aeed whether genetic variation in autophagy genes contributes to susceptibility to develop thyroid carcinoma, disease progreion and/or patient outcome.The results indicate that patients carrying the ATG5 single nucleotide polymorphisms rs2245214 have a higher probability to develop thyroid carcinoma(OR 1.85(95% CI 1.04–3.23),P = 0.042).In contrast, no significant differences could be observed for the other genetic variants studied in terms of thyroid carcinoma susceptibility.Furthermore, none of the selected genetic variants were aociated with clinical parameters of disease progreion and outcome.In conclusion, genetic variation in ATG5, a central player in the autophagy proce, is found to be aociated with increased susceptibility for thyroid carcinoma, indicating a role for autophagy in thyroid carcinogenesis.细胞自噬是在细胞存活，细胞死亡和细胞增殖的调控一个重要过程并且在肿瘤发生中也起着重要作用，包括甲状腺癌。基因变异在细胞吞噬部分已经被证明对执行细胞吞噬的能力存在影响和对疾病的易感性，发展和预后有关。在本研究中，我们评估了自噬基因的遗传变异是否有利于评估甲状腺癌的易感性，病人的病情进展和预后。结果表明，携带ATG5单核苷酸多态性rs2245214的患者发展为甲状腺癌的概率更高（OR1.85（95％CI1.04-3.23），P = 0.042）。相反的是，在关于甲状腺癌易感性其他基因遗传的研究中并不存在特异性，此外，不存在已经选择的基因变异和疾病的进展和预后的临床指标存在联系。总得来说，在ATG5的基因变异，在细胞自噬过程的一个关键因素，被发现与甲状腺癌的易感性增加有关，表明了细胞自噬在甲状腺癌中的作用。
