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细胞工程Cell Engineering
Instructors:Song Li, Profeor of Bioengineering, University of California, Berkeleysongli.bioe@gmail.com
Amina Qutub, Aistant Profeor of Bioengineering, Rice University
aminaq@rice.edu
Teaching Aistant: None
Lecture:2 weeks
Prerequisites: Basic concepts on cell biology and stem cells;differential equations and
basic linear / matrix algebra
Homework: Study reference papers, prepare for the discuion next day,computational simulation(laptop or desktop computer is sufficient for
computer simulation)
Final: Presentation of computational simulation and a proposed research project
in the cla
细胞工程是近年来飞速发展的一个领域，对于组织工程，再生医学，体外疾病模型及药物筛选都具有极其重要的价值和意义。这也是一个在生物，医药，工程，生物材料，系统生物学和干细胞研究前缘的交叉学科。在以上任何一个领域研究生都需要学习用跨学科交叉的视点来从事这方面的研究。这门课将教授生物工程，干细胞工程和系统生物学的知识，结合实验和计算模拟的实例，训练研究生的跨学科思维，并通过分析讨论最新的国际研究范例，帮助研究生实现从知识到创新研究，从单一学科到跨学科思维的飞跃。
Discher DE, Mooney DJ, Zandstra PW.Growth factors, matrices, and forces combine and control stem cells.Science.2009 Jun 26;324(5935):1673-7.Takahashi K, Yamanaka S.Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors.Cell.2006 Aug 25;126(4):663-76.Hou P, Li Y, Zhang X, Liu C, Guan J, Li H, Zhao T, Ye J, Yang W, Liu K, Ge J, Xu J, Zhang Q, Zhao Y, Deng H.Pluripotent stem cells induced from mouse somatic cells by small-molecule compounds.Science.2013 Aug 9;341(6146):651-4.Downing TL, Soto J, Morez C, Houin T, Fritz A, Yuan F, Chu J, Patel S, Schaffer DV, Li S.Biophysical regulation of epigenetic state and cell reprogramming.Nat Mater.2013
Dec;12(12):1154-62
Obokata H, Wakayama T, Sasai Y, Kojima K, Vacanti MP, Niwa H, Yamato M, Vacanti CA.Stimulus-triggered fate conversion of somatic cells into pluripotency.Nature.2014 Jan 30;505(7485):641-7.Pang ZP, Yang N, Vierbuchen T, Ostermeier A, Fuentes DR, Yang TQ, Citri A, Sebastiano V, Marro S, Südhof TC, Wernig M.Induction of human neuronal cells by defined transcription factors.Nature.2011 May 26;476(7359):220-3.Houk et al.Membrane tension maintains cell polarity by confining signals to the leading edge during neutrophil migration.Cell.2012 Jan 20;148(1-2):175-88
Hartwell KA et al.Niche-based screening identifies small-molecule inhibitors of leukemia stem cells.Nat Chem Biol.2013 Dec;9(12):840-8.Chuang HY, et al.Subnetwork-based analysis of chronic lymphocytic leukemia identifies pathways that aociate with disease progreion.Blood.2012 Sep 27;120(13):2639-49.Hofree M, Shen JP, Carter H, Gro A, Ideker T.Network-based stratification of tumor mutations.Nat Methods.2013 Nov;10(11):1108-15.Syllabus(2 hours for each day;20 hours total)
(Li)
Day 1 Course overview and introduction(Li/Qutub)Cell engineering: Scope and approaches(Li)Systems biology and design of virtual experiments(Qutub)Day 2 Cell signaling: cell-cell, soluble factors, adhesion substrate, biophysical regulation Signaling network analysis(Qutub)Day 3 Case study #1: Cell signaling-computer simulation(Qutub)Cell migration-the mechanisms(Li)Engineering the microenvironment to guide cell migration(Li)Day 4 Modeling cell dynamics(Qutub)Case study #2: Cell dynamics simulation(Qutub)Day 5 Stem cell expansion, differentiation, therapy(Li)Engineering the niche of stem cells(Li)Day 6 Computational cell phenotyping(Qutub)Case study #3: Engineering stem cell fate(Li)Day 7 Cell reprogramming using transcriptional factors(Li)
Cell reprogramming using microenvironmental factors(Li)
Day 8
Case study #4: Cell reprogramming(Li)
Multiscale modeling of tiue formation(Qutub)
Day 9
Case study #5: Cells for tiue engineering(Li)
Case study #6: Cells and tiues for drug screening(Li/Qutub)
Day 10
Project presentation by students
医学影像技术前沿
联系授课教授、专家的科研、设计实际，讲授医学影像技术的前沿、进展及应用。授课教师均为长期从事医学影像研究、开发与应用的一线教授、专家，充分体现本课程的专业性和前沿性。海外教授讲授一半课时以上，授课教师还有来自工业界的专家。
教学方式：课堂教学+师生讨论+上海联影医疗科技有限公司，通过积极的教学互动向学生介绍医学影像技术的前沿、进展及应用。
教学内容
1、磁共振成像技术最新发展及展望
2、一体式PET-MRI：基本原理与临床、科研应用
3、脑功能核磁共振成像简介
4、如何用无创的方法来测量人脑的血液供给：动脉自旋标记磁共振简介
5、低剂量CT技术
6、相衬成像技术
7、Medical Image Registration8、Neuroimage-based Diagnosis of Brain Disorders9、参观上海联影医疗科技有限公司
生物医学研究中的伦理及规范
授课内容
（1）Howto write and publish a scientific paper；
Definition of plagiarism
Rules for citing the references
Ethics and rules in data analysis and presentation
（2）Ethics of using Animals；
Rules Animal care and Usage；
Animal Experimental Protocols；
Safety in Animal Care and Usage
Animal handling
（3）Laboratory and Clinical Human experiments；
Declaration of Helsinki
Procedures of Institutional Review Board
（4）Ethics in Engineering Design
Relationship between person, society and engineering profeional Ethics in Engineering design
（5）Ethics in academic communication and collaboration
Intelligence Properties and Authorship；
Ethics in biomedical engineering research
授课专家：
生物医学工程学院童善保教授
生物医学工程学院古宏晨教授
美国西北大学John Troy
国内校外教师一名 待定
超声成像实验
教学内容
2014.7.8上午 2 hours
2014.7.11
2014.7.15
2014.7.18
2014.7.22
2014.7.25
详见附件 上午2 hours 上午 3hours 上午 3 hours 上午 3 hours 上午 3 hours Dc.Niu Physical basic of ultrasound(in Chinese)Dc.Niu Physical basic of ultrasound(in Chinese)Prof.Fowlkes Prof.Fowlkes Prof.Fowlkes Lab course of B-mode imaging(in English)Lab course of Doppler imaging(in English)Group work教授 Student presentation and discuion
