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• A goal of Genomics is to find and expre genes that code for
unknown peptides with significant biological properties, like receptors or enzymes.In a reverse Pharmacology approach this peptide, e.g.a receptor, is then used to “fish” for a natural ligand.With receptor and ligand in hand the biological role of the receptor needs to be determined.Finally, screening for synthetic ligands as well as lead optimization can lead to new drug candidates.In contrast, the claical approach to drug discovery starts with the identification of a ligand that has biological activity that in turn is used to “fish” for the corresponding receptor.基因组学的目标是寻找和表达为具有重要生物特性的肽指定遗传密码的基因,如受体或酶。用反相药理学处理肽，,如受体,然后用它“寻”天然配体。受体和配体进行结合时，受体的生物作用需要确定。最后,筛选合成的配体以及最佳化合物设计可能会产生新药物的候补者。相比之下,经典的药物发现方法是从一个具有生物活性的配体的识别开始，依次“寻”相应的受体。•
• One example for a Genomics strategy aims at identifying drug targets
based on molecular homology within Gene-families.One of the most important families of drug-targets for the pharmaceutical industry is the family of G-protein coupled receptors(GPCRs).Of the top 200 best selling prescription drugs, more than 20% interact with GPCRs, providing worldwide sales of over $20 billion.The characteristic motif of the GPCR family is the seven distinct hydrophobic regions, each of 20 to 30 amino acids that form the transmembrane domain of these integral membrane proteins.This key amino-acid sequence motif can be found within all types of GPCRs and can be used to identify DNA-sequences that code for GPCRs.• 例如一个基因组策略目的在于在分子内同源性的基因家族的基础上识别药物的靶点最重要的一个家庭制药业的drug-targets G-protein耦合的受体家族(GPCRs)。最高的200年最佳销售处方药,20%以上与GPCRs交互,提供超过200亿美元的全球销售。GPCR的特色主题家庭七个不同的疏水区域,每个20到30个氨基酸构成的膜域积分膜蛋白质。这个关键氨基酸序列图案中可以找到所有类型的GPCRs,可以用来确定GPCRs DNA-sequences代码。
